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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIP5K1C All Species: 18.79
Human Site: S448 Identified Species: 45.93
UniProt: O60331 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60331 NP_036530.1 668 73260 S448 N T V F R K N S S L K S S P S
Chimpanzee Pan troglodytes XP_512274 753 81943 V533 S G T G R G L V A L K S S P S
Rhesus Macaque Macaca mulatta NP_001130039 550 61219 R339 T Q Y S V D T R R P A P Q K A
Dog Lupus familis XP_542172 761 83011 S546 N T V F R K N S S L K S S P S
Cat Felis silvestris
Mouse Mus musculus O70161 661 72390 S448 S T V F R K S S S L K S S P S
Rat Rattus norvegicus Q5I6B8 688 75576 S448 S T V F R K S S S L K S S P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511349 767 84935 S443 N T V F R K N S S L K S S P S
Chicken Gallus gallus Q5ZJ58 540 60700 T328 V V T E T T N T M G G I P A K
Frog Xenopus laevis Q5PQ01 419 47633 R208 D S Y I I V M R N M F S H R L
Zebra Danio Brachydanio rerio Q6IQE1 416 47361 H205 V M R N M F S H R L L V H R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.6 55.2 82.3 N.A. 91.3 87.2 N.A. 74.1 52.6 21.7 21.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 86.4 65.4 84 N.A. 94.3 90.6 N.A. 78.6 64.9 35.7 35.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 46.6 0 100 N.A. 86.6 86.6 N.A. 100 6.6 6.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 60 6.6 100 N.A. 100 100 N.A. 100 13.3 33.3 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 10 0 10 0 0 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 50 0 10 0 0 0 0 10 0 0 0 0 % F
% Gly: 0 10 0 10 0 10 0 0 0 10 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 20 0 0 % H
% Ile: 0 0 0 10 10 0 0 0 0 0 0 10 0 0 0 % I
% Lys: 0 0 0 0 0 50 0 0 0 0 60 0 0 10 20 % K
% Leu: 0 0 0 0 0 0 10 0 0 70 10 0 0 0 10 % L
% Met: 0 10 0 0 10 0 10 0 10 10 0 0 0 0 0 % M
% Asn: 30 0 0 10 0 0 40 0 10 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 10 0 10 10 60 0 % P
% Gln: 0 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 0 10 0 60 0 0 20 20 0 0 0 0 20 0 % R
% Ser: 30 10 0 10 0 0 30 50 50 0 0 70 60 0 60 % S
% Thr: 10 50 20 0 10 10 10 10 0 0 0 0 0 0 0 % T
% Val: 20 10 50 0 10 10 0 10 0 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 20 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _